Tangential Flow Filtration (TFF), also called Cross Flow Filtration (CFF), is a rapid and efficient method for filtration and separation of solutions containing biomolecules, or particles such as viruses, bacteria or cellular material. It is a process whereby product flow (feed) is directed tangentially along the surface of a membrane with most of the solution circulated back to teh feed tank.
Minim II Tangential Flow Filtration System
Minim II Tangential Flow filtration system
The Minim II System, a benchtop TFF system, provides biotechnology and biopharmaceutical drug developers and manufacturers with the tools to optimize processes and minimize development times. the Minim II TFF system is an ideal instrument for running filterability at ultra-low volumes, since it allows users to accurately scale-up process conditions and maximize yields.
- User friendly interface
- Ease of Data Collection
- Calibrated Instrumentation
Centramate 500 S Tangential Flow Filtration System
The Centramate 500 S benchtop TFF system provides biotechnology and biopharmaceutical drug developers and manufacturers with an ultra-compact portable unit for process development in ultrafiltration (UF) and microfiltration (MF) applications.
- Compact flowpath
- Scalable Process Technology
- Direct Flow Filtration
- High Yield and Product Recovery
- Pressure independent
Hollow Fibre Modules: Microza
T-Series TFF Cassettes with Omega Membrane
High Performance Omega PES Membrane combined with Significant Material and Design Improvements Deliver Highly Reliable Fluid Dynamics and Better Process Economics
- Easy implementation into your process
- Increased safety, reliability and reproducibility
- High flux, high selectivity and low protein binding
- Improved process performance
- Easy scale up for robust purification processes
Microza ultrafiltration membranes are unique in their construction. Every membrane has an asymmetric structure, with a membrane layer both on the inside and on the outside of the fiber, overlaying a core comprising of a very open support for excellent flow characteristics, and a central strengthening layer for outstanding fiber durability in long-term service. Microza ultrafiltration membranes are resistant to flow in both directions, so their is no risk of delamination or membrate rupture during accidental back-pressure. In fact, in many installations, backpulsing can be used to maintain flux during extended run times.
Pall's PASS Engineering custom-made filtration
Pall's PASS Engineering group, in Collaboration with BBI Enzymes, designed a custom-made ultra filtration skid for their Horse Radish Peroxidase production. After small scale lab trials, PASS were able to upscale to a production system. Making use of Pall's Microza Hollow Fibre modules PASS' system is able to concentrate and clarify BBI's product at significantly improved process times.
